You Position: Home > Paper
Clinical Significance of Synchronous Detection of β2-microglubin and β-glucuronidase in CSF of Patients With Cerebral Tumor
( views:260, downloads:0 )
- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.03.004
- Key Word:
- 脑肿瘤;β-葡萄糖醛酸酶;β2微球蛋白
Abstract： 目的探讨脑肿瘤患者脑脊液中β2微球蛋白和β-葡萄糖醛酸酶(β-G)活性测定的临床意义.方法分别采用放免法和ELISA技术测定脑肿瘤及非肿瘤脑病患者脑脊液中β2微球蛋白和β-G活性.结果恶性脑瘤患者脑脊液中无论β2微球蛋白和β-G活性均明显高于良性脑瘤和头痛患者,分别为P＜0.05和P＜0.01;且恶性脑瘤患者脑脊液中两者增高程度呈正相关,但与肿瘤大小、恶性程度无关;其中恶性脑瘤患者脑脊液中β-G活性术后呈下降趋势.结论脑脊液中β2微球蛋白和β-G活性测定对恶性脑肿瘤诊断有一定的辅助参考价值;β-G活性测定对恶性脑肿瘤病程判定有一定临床意义.
- [1]杨波,张弘,王浩.肝癌患者血清及癌组织中β-葡萄糖醛酸酶同步测定及意义[J].1999,(1).
- [2]杨波.ELISA测定血清β-葡萄糖醛酸酶及临床应用[J].1998,(5).
- [3]P J Finch,F P Ryan,K Rogers,etc.Gastric enzymes as a screening test for gastric cancer.[J].1987,28(3).
- [4]张弘,温海彦,杨波,等.胰腺导管上皮细胞与胰腺癌细胞内β-葡萄糖醛酸酶免疫电镜定位研究[J].1998,(5).
- [5]S. Clifford Schold,William R. Wasserstrom,Martin Fleisher,etc.Cerebrospinal fluid biochemical markers of central nervous system metastases[J].1980,8(6).
- [6]缪体宗,唐文渊,傅雅各.中枢神经系统肿瘤组织β-葡萄糖醛酸酶的变化及临床意义（摘要）[J].1993,(2).
- [7]T R, Koch,K M, Lichtenfeld,P H, Wiernik.Detection of central nervous system metastasis with cerebrospinal fluid beta-2-microglobulin.[J].1983,52(1).