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Value of Tumor Markers in the Differential Diagnosis of Malignancy-related and Non-malignant Ascites
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1008-1372.2003.01.005
- Key Word:
- 腹水;诊断;鉴别诊断;肿瘤标志物
Abstract： 目的探讨鉴别良恶性腹水的新方法.方法比较几组患者152例血清及腹水肿瘤标志物(AFP、CEA、CA19-9及CA125)的情况.结果恶性腹水组血清AFP、CEA、CA19-9及CA125水平较良性腹水组显著升高(P＜0.01).血清AFP、CEA、CA19-9及CA125诊断恶性腹水的敏感性分别为75.0%, 73.8%, 63.6%及66.7%, 特异性分别为86.4%,77.6%,88.4%及74.1%.在鉴别结核、肝硬化与恶性腹水时, 以CA125≥400KU/L为阳性界值更为适当,可提高诊断的特异性及准确性.以AFP≥400ng/ml为阳性界值可提高诊断原发性肝癌的特异性.血清AFP及CEA联合检测可提高诊断恶性腹水的敏感性至94.7%.结论检测肿瘤标志物(AFP、CEA、CA19-9及CA125)有助于良恶性腹水的鉴别诊断,血清AFP及CEA联合检测可提高诊断恶性腹水的敏感性.
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