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Renoprotective Effects of Benazepril on Rat Kidney After Unilateral Ureteral Obstruction
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 7
- DOI:
- 10.3760/cma.j.issn.1008-1372.2002.07.006
- Key Word:
- 输尿管,阻塞;苯那普利;动物模型,大鼠
Abstract： 目的研究单侧输尿管梗阻后肾间质纤维化的发生机理及血管紧张素转换酶抑制剂苯那普利对其保护作用.方法将24只大鼠随机分为假手术组即对照组、手术组和苯那普利组,采用单侧输尿管梗阻(UUO)模型,术后2周观察梗阻肾组织病理改变,应用免疫组织化学方法检测肾间质Ⅲ型胶原,转化生长因子β1(TGF-β1)和核因子-kB(NF-kB)的表达.并应用放射免疫法检测血浆和肾组织血管紧张素Ⅱ(AngⅡ)的含量.结果手术组肾间质Ⅲ型胶原,TGF-β1和NF-kB的表达增加,血浆和肾组织AngⅡ增高,与对照组相比有显著差异(P＜0.05).苯那普利组与手术组相比Ⅲ型胶原、TGF-β1、NF-kB的表达下调,AngⅡ减少,差异显著(P＜0.05).结论苯那普利可能通过阻断AngⅡ的作用和抑制TGF-β1、NF-kB的过度表达,使肾间质Ⅲ型胶原沉积减少而产生保护肾脏作用.
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