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The Inhibition of Losartan to Glomerulosclerosis in SHR
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1008-1372.2002.05.006
- Key Word:
- 高血压;肾小球硬化;血管紧张素Ⅱ;血管紧张素Ⅱ受体拮抗剂
Abstract： 目的探讨洛沙坦(Losartan)对肾小球的保护作用.方法由高血 压组(SHR)和正常对照血压组(WKY鼠)组成,其中SHR组再分为治疗组和非治疗组,分别 于3月龄和8月龄测量鼠尾动脉压及电子显微镜下有关超微结构计量指标.血管紧张素Ⅱ受体拮抗剂选用Losartan 20mg·Kg-1·d-1.结果与正常血压对照组比较,高血压鼠血管内皮 细胞、系膜细胞体密度明显增大)P＜0.01),显示增生较前者活跃,可见较多的电子致密物 聚积并使整个系膜区体密度扩大(P＜0.01).Losartan治疗后系膜区体密度及细胞外基质较 非治疗组明显减小(P＜0.01).结论 ATⅡ受体拮抗剂在降低动脉压同时,能有效地保护肾脏,延缓高血压肾小球硬化进程.
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