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Changes of Serum Endotoximia and Interleukin-6 Levels Before and After Treatment at Intestine Depollution and Adjustment Intestine Microenvironment in Patients With Liver Cirrhosis
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1008-1372.2002.03.005
- Key Word:
- 肝硬化;IL-6;内毒素血症;腹水;自发性腹膜炎
Abstract： 目的观察晚期肝硬化患者肠道去污、调整肠道微环境治疗前后血清内毒素、IL-6水平的变化以及自发性细菌性腹膜炎(SBP)的发生率,寻找一种能够更有效降低SBP发生率的方法.方法 A组:给予保肝、补充人体白蛋白、利尿等常规治疗;B组:在常规治疗的基础上每2周给予氟哌酸(FPA)0.2g,tid,po,连服3d;C组:在B组治疗的基础上,停用FPA后给予肠复康0.5g,tid,po,肠泰口服液10ml,tid,po.乳果糖10ml,tid,po.共8周.结果 A组治疗前后血清内毒及IL-6水平无明显变化,SBP发生率明显高于B、C组;B组治疗后血清内毒素及IL-6下降,SBP发生率降低;C组治疗后血清内毒素及IL-6明显下降,SBP发生率明显降低,与A、B组比较差异均有显著性.结论肠道去污、调整肠道微环境治疗可有效的降低内毒素血症及IL-6水平,使SBP发生率明显降低.
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