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The Diagnostic Strategy in Gastroesophageal Reflux Disease and the Role of Acid Inhibition Therapeutic Test
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1008-1372.2002.02.006
- Key Word:
- 胃食管反流;治疗;诊断;胃酸抑制剂
Abstract： 目的评价胃食管反流病(GERD)诊断方法及质子泵抑制剂(PPI)治疗试验的价值.方法对104例有烧心、反酸或反食,伴有或不伴有非心源性胸痛、咽下疼痛及平卧时呛咳等症状的患者进行症状评分、内镜检查、食管测压、2h食管腔内pH监测和7d的安慰剂或兰索拉唑(30mg,每天2次)随机分组交叉对照治疗试验;以24h食管下段pH＜4的总时间＞4%或和/反流总评分＞14分作为诊断病理性胃食管酸反流的标准;用PPI抑制治疗第5、6、7共3d的症状总评分与用药前3d的症状总评分相比较,以症状总分下降＞75%者为治疗试验阳性.结果 104例中内镜检出食管炎18例(17%);烧心为主要症状者83例(80%);pH监测结果符合病理性胃食管酸反流(GERD)者87例(84%);兰索拉唑治疗试验阳性者85例(82%),两种诊断方法的结果显著相关(P＜0.01).胃镜及食管测压对GERD的检出率低,由24h食管pH监测诊为GERD者87例中,治疗试验阳性者82例(敏感性94%),pH监测结果阴性者的另17例中,治疗试验阴性14例(特异性82%),兰索拉唑治疗试验对诊断GERD的准确性为92%.结论对有典型胃食管反流症状的患者,质子泵抑制剂抑酸治疗试验用于辅助诊断GERD可先于食管测压及24h食管腔内pH监测进行,它具有较高的敏感性及特异性,且简便易行,具有较高的临床价值.
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