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Efects of 5 - aza - 2' - Deoxycytidine and Arsenic Trioxide on Myeloid Leukemia Cells
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2001.09.009
- Key Word:
- 5-氮-2'-脱氧胞嘧啶;三氧化二砷;HL60;凋亡;诱导分化
Abstract： 目的研究5-氮-2'-脱氧胞苷与三氧化二砷联合作用于HL60白血病细胞.方法培养粒系白血病细胞,与5-氮-2'-脱氧胞苷、三氧化二砷一起培养后用生长曲线、表面分化抗原、细胞周期二倍体峰及过氧化物酶等指标来测定其抗肿瘤作用.结果5-氮-2'-脱氧胞苷与三氧化二砷均有抑制生长曲线、诱导分化作用,两者合用后作用比单用强.结论三氧化二砷可增强5-氮-2'-脱氧胞苷的抗肿瘤作用.
- [1]R.L. Momparler,B.T. Doré,L.F. Momparler.Effect of 5-aza-2′-deoxycytidine and retinoic acid on differentiation and c-myc expression in HL-60 myeloid leukemic cells[J].1990,54(1-2).
- [2]Benoit T. Doré,Christine ChomienneRichard L. Momparler.Effect of 5-aza-2′-deoxycytidine and vitamin D3 analogs on growth and differentiation of human myeloid leukemic cells[J].1998,41(4).