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Pathologic Changes on Glomerulic Area in Non-Dependent Diabetes Mellitus(Type 2 DM) Patients

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Author:
No author available
Journal Title:
Journal of Chinese Physician
Issue:
3
DOI:
10.3760/cma.j.issn.1008-1372.2001.03.006
Key Word:
2型糖尿病;肾小球系膜基质*;肾小球硬化*

Abstract: Objeetive To explore the relationship among the glomerularmesangium components,degree of renal lesion and glomerulosclerosis in patients with type 2 DM.Method A quantitative study of type Ⅳ collagen in kidneys taken from twenty-one patients with type 2 DM and ten-two control autoptical renal tissue specimens were investigated by immunochemical techniques,computer image analysis system.Results The amounts of type Ⅳ collagen were increased parallel with advances of glomerulosclerosis and renal arteriolosclerosis in patients with type 2 DM,but the collagen had not obviously elevation in renal failure patients.Conclusions The increased type Ⅳ collagen is a characteristic manifestation of early and moderate lesions of glomerulosclerosis in type 2 DM.Quantitative determination of glomerular mesangium components could be a good index to judge the lesion degree of kidney.

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