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Detection and Evaluation of bcl-2and c-myc Gene Expression in Bone Marrow Cellws From Patients with Acute Myeloid Leukemia
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-1372.2000.10.007
- Key Word:
- 白血病;基因;bcl-2;c-myc
Abstract： 为探讨凋亡调控基因bcl-2、c-myc对白血病的发生、疗效及预后判定的意义,采用免疫组化法检测bcl-2、c-myc在72例急性髓系白血病患者骨髓细胞中的表达.结果发现初治和复发者bcl-2、c-myc的表达比完全缓解组和对照组明显增高(P＜0.01);初治组和复发组之间差异无显著性(P＞0.05);bcl-2与c-myc的表达呈正相关(P＜0.01);bcl-2和/或c-myc高度表达的患者对治疗的反应比低表达者差(P＜0.01).说明bcl-2、c-myc高表达与白血病的发生、疗效及预后密切相关.
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