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Expression of CD15,p53,c - erbB - 2 and PCNA in Bladder Carcinoma and their Relationship
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-1372.2000.10.006
- Key Word:
- 膀胱肿瘤;CDl5;p53;c-erbB-2;增殖细胞核抗原;免疫组织化学
Abstract： 为研究CDl5、癌基因和抑癌基因蛋白产物在膀胱癌组织中的表达与病理分级、临床分期、复发和转移的关系,并探讨CDl5与癌基因和抑癌基因蛋白表达的相关性.应用微波-LSAB免疫组织化学法,检测52例膀胱癌组织中CDl5、p53、c-erbB-2和增殖细胞核抗原(PCNA)的表达水平.结果显示在膀胱癌中CD15、p53、c-erbB-2和PCNA阳性表达率分别为69.2%、48.1%、38.1%和53.8%,其表达均与肿瘤分级、分期、复发和转移相关(P＜0.05).CDl5与p53、c-erbB-2和PCNA表达呈正相关(r=0.4～0.47).说明CD15、p53、c-erbB-2和和PCNA均是膀胱癌高度恶性和预后不良的重要生物学指标.膀胱癌CD15表达可能与p53、c-erbB -2和PCNA蛋白表达具有密切关联性.
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