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The Effects of Angiotensin Ⅱ Receptor Antagonist on Concentration of Endothelin Level in Plasma of Diabetic Nephropathy
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- Author:
- No author available
- Journal Title:
- JOURNAL OF CHINESE PHYSICIAN
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.1008-1372.2000.10.004
- Key Word:
- 糖尿病肾病;血管紧张素Ⅱ受体拮抗剂;内皮素
Abstract： 观察Ang Ⅱ受体拮抗剂对DN患者血浆ET水平的影响.用RIA法测定正常对照组、DN患者用Losartan治疗前后的血浆ET浓度并检测与DN诊治有关的各项指标.DN患者经Losartan治疗后血浆ET明显降低,但水平仍显著高于正常对照组.(1)Losartan治疗可使DN患者血浆ET浓度降低,并与血糖、血压、蛋白尿、肾功能改善呈正相关;(2)6～8周的Losartan治疗不能使患者血浆ET恢复正常水平,提示DN病理生理过程及影响因素十分复杂.
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