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Junction proteins and transporter proteins of brain choroid plexus and their research progress in the field of pharmacology and toxicology

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Author:: No author available

Journal Title:: Chinese Journal of Pharmacology and Toxicology

Issue:: 1

DOI:: 10.3867/j.issn.1000-3002.2012.01.025

Key Word:: 脉络丛;血-脑脊液屏障;连接蛋白;转运蛋白;药理;毒理

Abstract：脑脉络丛组织是血-脑脊液屏障的物质基础,也是脑脊液的重要来源.其上皮细胞之间的紧密连接由连接蛋白组成,是维持细胞间机械屏障的结构基础,不仅具有调节细胞间物质流动和维持上皮细胞极性的功能,而且还参与细胞增殖分化和基因转录等过程的信息传递与调控；其上皮细胞膜上分布的各种转运蛋白,不仅在提供营养和激素等脑组织生长发育所必需的物质、清除脑脊液中的一些有害化合物及代谢物方面起关键作用,而且在药物与毒物的运输调控方面也起着至关重要的作用.这些连接蛋白和转运蛋白构成一个复杂的相互关联的网络结构,在维持脑室生理稳态以及保护脑组织免受内源性和外源性有害物质损害方面发挥着非常重要的作用,近年来备受关注.本文就脑脉络丛组织的连接蛋白、转运蛋白及其药理学与毒理学方面的研究进展作一综述.

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