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Progress in antitumor effect of cucurbitacin B and its mechanism

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Author:: No author available

Journal Title:: Chinese Journal of Pharmacology and Toxicology

Issue:: 1

DOI:: 10.3867/j.issn.1000-3002.2012.01.023

Key Word:: 葫芦素B;抗肿瘤药;STAT3转录因子;细胞骨架;微丝

Abstract：葫芦素是从葫芦科等植物中分离的三萜类天然产物,具有多种药理作用.葫芦素B是葫芦素家族的重要成员,对多种肿瘤具有抑制作用,是潜在的抗肿瘤药物.葫芦素B能够抑制肿瘤细胞STAT3转录因子的活化,干扰丝裂原活化蛋白激酶信号转导通路,诱导细胞周期阻滞于G2/M期,诱导肿瘤细胞凋亡,引起细胞骨架变化.越来越多的研究表明,葫芦素B的抗肿瘤作用可能与其破坏肌动蛋白细胞骨架的活性密切相关.本文综述了葫芦素B的抗肿瘤作用及其可能的机制.

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