You Position: Home > Paper

Clinical observational study of anemia in mechanically ventilated patients

( views:672, downloads:144 )
Author:
No author available
Journal Title:
Chinese Critical Care Medicine
Issue:
2
DOI:
10.3760/cma.j.issn.1003-0603.2012.02.004
Key Word:
机械通气;贫血;输血;预后;Mechanical ventilation;Anemia;Transfusion;Outcome

Abstract: Objective To explore the prognostic effects of anemia among the mechanically ventilated patients.Methods A prospective observational study was undertaken in a 12-bed intensive care unit (ICU).Patients requiring mechanical ventilation for at least 72 hours and hemoglobin (Hb)≥100 g/L were enrolled.Serum erythropoietin (EPO),Fe3+,transferrin (TRF) levels were measured as baseline when they were enrolled and were repeated at day 3,7 and 14.According to Hb concentration at day 3,patients were divided into anemia group (defined as Hb< 100 g/L)and non-anemia group.Serum EPO,Fe3+,TRF at day 1,3 and 7,and mean amount of blood transfusion within 14 days,mean volume of blood drawn daily in 3,7 and 14 days,the survival rate with unassisted breathing at day 28,ICU mortality,length of ICU stay,ventilator days,length of hospital stay and 28-day mortality were compared.Results Forty mechanically ventilated patients were enrolled and divided into anemia group (n =18 ) and non-anemia group (n=22).It was shown that the anemia group had lower serum Fe3+ concentration,and higher serum EPO and TRF.The anemia group also had more transfusion [ U:4.0 ( 2.0,6.0) vs.2.0 (0.0,2.0),P< 0.01],longer length of hospital stay [ days:35.0 ( 16.5,51.6) vs.24.5 ( 10.0,35.8 ),P<0.05],decreased rate of survival with unassisted breathing at day 28 (44.4% vs.72.7%,P<0.05) and higher ICU mortality (44.4% vs.13.6%,P<0.05 ).But there were no significant differences between anemia group and control group in mechanical ventilated days (days:18.3 ± 10.8 vs.11.6 ± 8.2,P>0.05),length of ICU stay [days:16.5 (8.0,21.5) vs.11.0 (5.8,18.3),P>0.05] and hospital mortality (61.1%vs.31.8%,P>0.05).Conclusion The anemic patients had longer ventilator days,hospital stay,higher ICU mortality,and lower rate of survival with unassisted breathing at day 28.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn