Abstract： Objective To observe the curative effect of total saponins of Panax notoginseng(PNS) on chronic renal failure(CRF). Methods Sixty patients with CRF(non-uremic) were randomly divided into the experimental and the control groups,with 30 cases in each group.Patients in experimental group were given PNS extract Xueshuantong(血栓通) 0.45 g on the basis of the general symptomatic treatment,once a day.While the patients in the control group were treated with Bailing capsule(百令胶囊) of 1.0 g,three times a day.Total therapeutic courses were 2 months for both groups.The changes in renal function,hemoglobin,24-hour urinary protein,parathyroid hormone(PTH),N-actely-β-D-glucosaminidase(NAG) were observed in two groups. Results After 2 months,the changes in serum creatinine(SCr),clearance rate of endogenous creatinine(CCr),blood urea nitrogen(BUN),uric acid(UA),hemoglobin,24-hour urinary protein were improved in both groups,while the changes in CCr,BUN,hemoglobin,24-hour urinary protein in the experimental group were more obvious[CCr(ml/s):0.36±0.13 vs.0.34±0.12,BUN(mmol/L):15.66±9.05 vs.20.32±8.30,hemoglobin(g/L):101.2±9.4 vs.95.4±8.7,24-hour urinary protein(mg):1 040±450 vs.2 360±390,all P<0.05].After treatment,NAG(U/L) were decreased significantly only in control group(18.2±9.8 vs.28.9±12.0,P<0.05). Conclusion PNS has a good therapeutic effect for the treatment of CRF(non-uremic).It possesses such therapeutic effects as improving the renal function,and lowering urine protein.