Evaluation of compliance with bundle treatment in the management of severe infection

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Author:
GUO Qi(Department of Respiratory Diseases,Affiliated Futian Hospital,Guangdong Medical College,Shenzhen 518033,Guangdong,China)
JIANG Mei(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
XU Yong-hao(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
XIAO Zheng-lun(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
LI Yi-min(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
NONG Ling-bo(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
XU Yuan-da(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
HE Guo-qing(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
HE Wei-qun(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
CHEN Si-bei(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
LIU Xiao-qing(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
LI Jing(Guangzhou Institute of Respiratory Disease,First Affiliated Hospital,Guangzhou Medical College,Guangzhou 510120,Guangdong,China)
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
Volume 21, Issue 01, 2009
DOI:
10.3760/cma.j.issn.1003-0603.2009.01.003
Key Word:
severe sepsis;septic shock;bundle treatment;compliance

Abstract: Objective To evaluate compliance with bundle treatment in the management of severe infection in a tertiary hospital,aiming at analyzing clinical data in order to popularize guidelines for management of severe sepsis and septic shock.Methods A 14-month(from November 1,2006 to December 31,2007)prospective observationsl study of a group of 43 patients admitted to the respiratory intensive care unit in First Affiliated Hospital(tertiary hospital)of Guangzhou Medical College meeting the criteria for severe pneumonia and septic shock was carried out.Implementation of 6-hour and 24-hour bundle treatment for severe infection was divided into three phases consisting of education,trial,and application.A cohort of 43 patients with matched disease history admitted during January 1,2004 to October 31,2006 were enrolled as control group.Results ① In 6-hour bundle treatment for severe infection,20.9%(9/43) had serum lactate meassured,blood culture was obtained prior to antibiotic administration in 7.0H(3/43)of patients,100%(43/43)had empirical antibiotics administration within 1 hour,an injusion of an initial minimum of 20 ml/kg of crystalloid or colloid equivalent(1.1 ml/kg of 20%albumin or 4.8 ml/kg of 6% hydroxyethyl starch)was given in 44.2%(19/43),with infused fluid(converted into 6% hydroxyethyl starch)reaching(503.95±176.19)ml within 6 hours,in 94.7%(18/19)of patients had received vasopressors,and inotropic dobutamine and/or transfusion of packed red blood cells were administered in 7.0%(3/43).② In 24-hour bundle treatment for severe infection group,31.6%(6/19)had received low-dose steroids,34.9%(15/43)had their blood glucose controlled<8.3 mmol/L,mechanical ventilation with inspiratory plateau pressures maintained<30 am H20(1 cm H2O=0.098 kPa,6 ml/kg tidal volume) was instituted in 97.6%(40/41)of patients.③ The percentage of compliance with 6-hour and 24-hour bundle treatment for severe infection were 0 and 21.4% respectively,total compliance was also 0.④ As compared with control group,a 23.30% absolute mortality reduction was found in bundle group(18.6%vs.41.9%,P=0.019).Conclusion Bundle treatment for severe infection is complied with partially in our hospital,suggesting that it is still quite arduous to popularize guidelines for management of severe sepsis and septic shock in our country.

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