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Effect of methylprednisolone on procollagen type Ⅲ of rats with acute lung injury

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
8
DOI:
10.3760/j.issn:1003-0603.2006.08.004
Key Word:
肺损伤,急性;Ⅲ型前胶原;甲基泼尼松龙

Abstract: 目的探讨甲基泼尼松龙对急性肺损伤(ALI)大鼠Ⅲ型前胶原(PCⅢ)的影响.方法将45只大鼠按随机数字表法分为内毒素损伤组(损伤组)、甲基泼尼松龙干预组(干预组)和对照组,每组15只.通过静脉注射内毒素(6 mg/kg)制备大鼠ALI模型,于制模后1、3和14 d各处死5只,观察各组支气管肺泡灌洗液(BALF)中细胞总数、中性粒细胞(PMN)分类、巨噬细胞分类及血清和BALF中PCⅢ水平变化.结果损伤组1 d BALF细胞总数、PMN分类及血清和BALF中PCⅢ水平即明显升高,与对照组比较差异均有显著性(P均<0.01),干预组上述指标均明显低于损伤组,差异有显著性(P<0.05或P<0.01).结论甲基泼尼松龙抑制内毒素所致ALI大鼠血清和BALF中PCⅢ水平升高,对ALI早期肺纤维化有抑制作用.

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