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Therapeutic effects of low molecular weight heparin and aspirin on acute lung injury in rat
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 8
- DOI:
- 10.3760/j.issn:1003-0603.2006.08.003
- Key Word:
- 肺损伤,急性;核转录因子-κB;低分子肝素;黏附分子
Abstract： 目的探讨核转录因子-κB(NF-κB)活化对急性肺损伤(ALI)大鼠P-选择素、细胞间黏附分子-1(ICAM-1)表达的影响,并观察低分子肝素(LMWH)和阿司匹林(ASA)对ALI的保护作用,并探讨其机制.方法尾静脉注射内毒素制备ALI大鼠模型.60只大鼠按随机数字表法分为正常对照组、ALI组、LMWH组和ASA组,每组15只.观察NF-κB、ICAM-1和P-选择素在肺组织中的表达情况.结果ALI组肺组织NF-κB活性显著增强;ICAM-1、P-选择素明显表达于血管内皮细胞和支气管上皮细胞膜(P均＜0.05);LMWH组和ASA组NF-κB、ICAM-1、P-选择素活性降低,炎症反应和病理损伤明显减轻,ASA组治疗效果优于LMWH组(P均＜0.05).结论NF-κB活化在ALI发病机制中起作用,NF-κB参与活化中性粒细胞、血管内皮细胞等多种炎症细胞,并且调控ICAM-1、P-选择素基因的表达进而造成肺组织损伤.LMWH通过改善微循环,间接抑制NF-κB活化,减少中性粒细胞及血小板的黏附进而减轻肺损伤.ASA通过抗氧化特性直接抑制NF-κB活化而减轻肺损伤.
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