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Protective effects of dexamethasone on myocardium in rats with sepsis
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1003-0603.2006.04.005
- Key Word:
- 脓毒症;脂多糖;肿瘤坏死因子-α;地塞米松
Abstract： 目的观察脓毒症大鼠心脏功能、心肌力学的改变并探讨地塞米松对心脏的保护作用及其机制.方法将96只Wistar大鼠随机分为对照组(32只)、脂多糖(LPS)组(32只,静脉注射LPS 4 mg/kg)及LPS+地塞米松组(32只,注射LPS的同时静脉注射地塞米松2 mg/kg).各组动物均于实验前(0 h)及给药后2、4和6 h采血(每个时间点8只).经右颈总动脉左心室内插管,监测各组动物左心室功能变化并检测血清肿瘤坏死因子-α(TNF-α)、血浆肌钙蛋白T(TnT)含量.结果①脓毒症状态下TnT显著升高;应用地塞米松后TnT明显降低[给药后6 h为(1.76±0.57)μg/L比(0.70±0.36)μg/L,P<0.01].②脓毒症状态下左心室收缩峰压(LVPP)、左心室压力上升/下降最大速率(±dp/dt max)均有不同程度变化,左心室舒张末期压(LVEDP)升高;应用地塞米松后可明显改善各项指标.③脓毒症状态下TNFα浓度明显升高,应用地塞米松可显著降低TNF浓度[给药后2 h为(11.22±2.38)pmol/L比(7.62±3.21)pmol/L,P<0.01].结论脓毒症状态下心肌可发生明显损伤;TNF-α为脓毒症状态下心肌损害因素;应用地塞米松可明显减轻内毒素对心肌的损伤.
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