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Changes of hemodynamics during establishment of animal model of acute myocardial infarction induced by ligation of left coronary artery in goat
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1003-0603.2006.04.003
- Key Word:
- 心肌梗死,急性;动物模型;循环功能;血流动力学
Abstract： 目的观察羊急性心肌梗死动物模型建立中血流动力学的变化.方法用剑突结扎法制备羊急性心肌梗死动物模型.观察心肌梗死前及梗死后即刻、30 min、1 h和2 h心电图(ECG)ST段、平均动脉压(MAP)、中心静脉压(CVP)以及心率的变化.结果术前描记ECG均正常.心肌梗死后即刻有8只、30 min有10只、2 h有18只羊可见ST段抬高;2只羊术中死亡.术后4周18只羊ECG描记均可见胸导联有病理性Q波;MAP、CVP和心率变化较心肌梗死前差异均无显著性(P均>0.05);有6只羊出现频发室性期前收缩,均经静脉注射利多卡因后消除.结论羊小范围心肌梗死动物模型建立对循环功能影响轻微,形成梗死可靠,术后动物可长期存活,为临床冠心病的实验研究提供了一个有价值的动物模型.
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