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Effects of ethyl pyruvate on splenocyte proliferation and apoptosis in burn rats with delayed resuscitation

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
7
DOI:
10.3760/j.issn:1003-0603.2005.07.004
Key Word:
烧伤;丙酮酸乙酯;T细胞;增殖;凋亡

Abstract: 目的观察丙酮酸乙酯对烫伤延迟复苏大鼠脾淋巴细胞增殖及凋亡的影响,并对其机制进行初步探讨.方法 72只Wistar大鼠随机分为假烫伤组(n=24)、烫伤组(n=24)和丙酮酸乙酯(3.23 mg/ml)治疗组(n=24),分别于伤后1、3和5 d活杀大鼠,检测脾淋巴细胞增殖能力及凋亡情况.结果烫伤延迟复苏后1~5 d,脾淋巴细胞对丝裂原刺激的增殖反应明显受抑制(P均<0.05);在烫伤后第1 d,脾CD3+ CD4+T细胞凋亡显著增加(P<0.05).应用丙酮酸乙酯治疗能够明显恢复烫伤后1~5 d脾淋巴细胞的增殖反应(P<0.05),同时烫伤后第1 d的凋亡明显下降(P<0.05).结论丙酮酸乙酯能够有效恢复烫伤延迟复苏后脾淋巴细胞的增殖能力,并减轻脾淋巴细胞凋亡.

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