You Position: Home > Paper
Changes in neuropeptide substance P and calcitonin gene-related peptide in scarless wound healing in fetal rabbit skin
( views:193, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1003-0603.2005.02.004
- Key Word:
- 创伤;无瘢痕愈合;神经肽;P物质;降钙素基因相关肽
Abstract： 目的探讨神经肽P物质(SP)和降钙素基因相关肽(CGRP)在无瘢痕愈合中的作用.方法建立胎兔背部皮肤全层切割伤模型,采用免疫组化方法观察神经肽SP和CGRP在胎兔创伤愈合中的动态变化特点,并与正常胎兔、创伤成兔和正常成兔进行比较.结果胎兔皮肤愈合快,伤后3～5 d完全无瘢痕愈合;成兔伤后第7 d瘢痕愈合.胎兔皮肤伤后SP和CGRP阳性表达降低,以第2 d最明显,分别为正常胎兔的75%和80%(P均<0.01),然后逐渐恢复正常;成兔皮肤伤后第1 d SP和CGRP表达明显降低,分别为正常成兔的60%和76%(P均<0.01),以后明显增加,第7 d达高峰,为正常成兔的168%和126%(P均<0.01),然后下降,第14 d与正常成兔基本相似.结论神经肽SP和CGRP的低表达在胎兔皮肤无瘢痕愈合中可能起重要作用.
- [1]谢江,赖西南,李华强,等.神经纤维在胎兔皮肤无瘢痕愈合中的变化[J].2003,(9).
- [2]Yongbo Li,Sung-Tsang Hsieh,Hsiung-Fei Chien,etc.Sensory and Motor Denervation Influence Epidermal Thickness in Rat Foot Glabrous Skin[J].1997,147(2).
- [3]Theodorsson E,Haegerstrand A,Bongenhielm U,etc.Effects of neuropeptides on growth of cultivated rat molar pulp fibroblasts.[J].1995,60(2).
- [4]A M, McDermott,T S, Kern,T W, Reid,etc.Effect of substance P, insulin-like growth factor-1 and vasoactive intestinal polypeptide on corneal re-epithelialization in galactosemic rats.[J].1998,17(12).
- [5]Frode Saleh-TS,Medeiros YS,Calixto JB.Analysis of the inflammatory response induced by substance P in the mouse pleural cavity.[J].1999,20(2).
- [6]孙晓庆,付小兵.几种神经内分泌肽与创伤修复[J].1999,(10).