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Effects of angiotensin-(1-7)on remodeling of myocardial collagen network in pressure-overloaded rats

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
9
DOI:
10.3760/j.issn:1003-0603.2004.09.005
Key Word:
血管紧张素;肥大,左心室;心肌纤维化;基因表达

Abstract: 目的探讨血管紧张素-(1-7)[Ang-(1-7)]对压力负荷增高大鼠心肌胶原网络重塑的影响.方法腹主动脉缩窄术制备压力负荷增高大鼠模型,75只SD大鼠随机分为假手术组、模型组、Ang-(1-7)治疗组(25 μg?kg-1*h-1,持续静脉给药).各组分别于术后1周和4周处死部分大鼠,检测左心室质量/体质量比以及心肌胶原容积分数,并采用逆转录聚合酶链反应检测左心室心肌Ⅰ、Ⅲ型胶原mRNA的表达水平.结果与假手术组比较,模型组和Ang-(1-7)治疗组术后1周Ⅰ、Ⅲ型胶原mRNA表达均明显增高,Ang-(1-7)治疗组增高的幅度明显低于模型组;模型组和Ang-(1-7)治疗组术后4周的左心室质量/体质量比、心肌胶原容积分数均高于假手术组,但Ang-(17)治疗组上述指标低于模型组.结论给予外源性Ang-(1-7)能减轻压力负荷增高所致的心肌胶原网络重塑.

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