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Association between a genomic polymorphism within the CD14 locus and severe sepsis susceptibility as well as prognosis in patients after extensive burns

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
5
DOI:
10.3760/j.issn:1003-0603.2004.05.005
Key Word:
烧伤;CD14;基因多态性;严重脓毒症;易感性;预后

Abstract: 目的探讨内毒素受体CD14C159T基因多态性与烧伤后严重脓毒症易感性及患者预后的关系.方法研究对象包括118例健康献血员和16例烧伤面积大于60%全身体表总面积的患者,通过分析HaeⅢ消化聚合酶链反应(PCR)产物的片段,对其进行CD14C159T基因多态性检测.研究CD14基因型的分布与严重脓毒症易感性及病死率的关系.结果 16例烧伤患者的等位基因频率(C 43.7%,T 56.3%)及基因型分布(C纯合子占12.5%,C/T占62.5%,T纯合子占25.0%)与健康献血员一致.发生严重脓毒症患者与非脓毒症患者基因型分布明显不同,严重脓毒症组T等位基因频率(71.4%)高于非脓毒症组(44.4%),TT纯合子患者发生严重脓毒症的比例有所增高.结论 CD14C159T基因多态性可能对烧伤后严重脓毒症的发生具有一定影响.

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