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Primary research of the effect of intestinal ischemia/reperfusion injury on Leptin concentrations
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 12
- DOI:
- 10.3760/j.issn:1003-0603.2003.12.005
- Key Word:
- 缺血-再灌注损伤,肠;Leptin;放射免疫分析法
Abstract： 目的:研究肠缺血-再灌注损伤对血清及脂肪组织Leptin水平的影响,探讨Leptin在急性炎症反应中的作用.方法:建立大鼠肠缺血-再灌注损伤模型,采用高灵敏鼠类Leptin放射免疫分析方法测量血清及脂肪组织Leptin浓度变化.结果:肠缺血60 min、再灌注损伤30 min后血清Leptin水平为(10.82±0.83)μg/L,相对于实验前的(16.46±3.21)μg/L有显著下降(P<0.05),而血清Leptin浓度高于脂肪组织水平(4.46±2.63)mg/100 g,并且两者的Leptin水平都有随损伤时间延长而逐步升高的趋势(P=0.047).结论:Leptin可能具有炎性细胞因子的作用,在肠缺血-再灌注损伤等急性炎症反应中可能发挥一定作用.
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