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Effect of vitamin E on myosin light chain kinase activity and endothelial permeability of the artery in atherosclerotic rabbit

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
8
DOI:
10.3760/j.issn:1003-0603.2003.08.004
Key Word:
肌球蛋白轻链激酶;维生素E;粥样硬化,动脉

Abstract: 目的:探讨维生素E(VitE)对动脉粥样硬化兔动脉肌球蛋白轻链激酶(MLCK)活性及内膜通透性变化的影响.方法:复制兔动脉粥样硬化模型,用γ-32P掺入法检测动脉MLCK活性,免疫荧光检测内膜通透性,同时用苏木精-伊红(HE)染色观察动脉壁的形态结构.结果:在喂饲胆固醇膳食4周的动物组,动脉MLCK活性与正常对照组比较显著升高(P<0.05);但在喂饲胆固醇膳食12周或同时添加VitE后,动脉MLCK活性与正常对照组比较升高不明显(P>0.05).荧光显微镜下观察显示,兔动脉内膜通透性在喂饲胆固醇膳食后4周有所增加,12周后显著增加;12周组膳食中同时加VitE后,通透性有所下降.结论:在动脉粥样硬化早期,内膜屏障完整性的改变可能与MLCK活性增强有关,VitE可能是降低动脉内膜MLCK活性的因素,并能降低动脉粥样硬化模型兔动脉内膜通透性.

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