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Gene expression of extracellularsignal regulated protein kinase1/2 and their MAPKKs in hypertrophic scars
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1003-0603.2003.04.003
- Key Word:
- 细胞外信号调节激酶1/2;MEK1基因;MEK2基因;增生性瘢痕
Abstract： 目的:探讨细胞外信号调节激酶1/2 (extracellular-signal regulated protein kinase,ERK1/2)及其上游信号分子MEK1/2在增生性瘢痕和正常皮肤中基因表达的变化.方法:提取8例增生性瘢痕和8例正常皮肤组织的总RNA后,分离mRNA,用逆转录聚合酶链反应(RT-PCR)法检测这4种基因在不同组织中的表达变化规律.结果:在正常皮肤组织中,MEK1、MEK2、ERK1和ERK2基因表达较弱;而在增生性瘢痕中,这4种基因表达明显增强,其mRNA量的灰度比分别为正常皮肤的1.1倍、1.2倍、2.2倍和2.5倍.结论:增生性瘢痕的发生可能与MEK1/2和ERK1/2基因表达升高有关.
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