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Changes in the percentage of human leukocyte antigen DR in CD+14 monocytes in burned patients
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1003-0603.2003.01.006
- Key Word:
- 代偿性抗炎反应综合征;CD+14;单核细胞;人白细胞DR抗原表达;烧伤;免疫麻痹
Abstract： 目的:探讨烧伤后外周血单核细胞表面人白细胞DR抗原受体(HLA-DR)的动态变化规律及意义.方法:选取临床烧伤患者30例,依据病程长短选取病程中1～5个时间点静脉采血,以流式细胞仪测定外周血单核细胞HLA-DR的表达率,并根据烧伤程度分组进行分析.结果:伤后患者外周血单核细胞HLA-DR的表达率明显降低,降低程度及持续时间与伤情有关,特重烧伤患者与中度烧伤患者[(4.30±1.50)%比(13.86%±2.40)%]、中度烧伤患者与轻度烧伤患者[(13.86±2.40)%比(58.80±5.60)%]比较差异均显著(P均<0.01).结论:单核细胞HLA-DR的表达率是反映免疫功能的简单实用的指标.重症烧伤后免疫麻痹可持续较长时间,必要的免疫加强治疗有重要意义.
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