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A small dose of intraperitoneal injection of zymosan induces systemic inflammatory response and multiple organ dysfunction following gut ischemia-reperfusion injury
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1003-0603.2003.01.003
- Key Word:
- 缺血-再灌注损伤;酵母多糖;实验模型,大鼠;多器官功能障碍综合征
Abstract： 目的:研究肠缺血-再灌注(I-R)损伤后腹腔注射小剂量酵母多糖对全身炎症反应和远隔器官的影响.方法:将雄性Wistar大鼠随机分为3组.二次打击组(M组)先阻断肠系膜上动脉血流60 min,于恢复肠道血流12 h腹腔注射小剂量酵母多糖(125 mg/kg);对照组分别实施单纯肠缺血再灌注损伤(I-R)或腹腔注射酵母多糖(Z).观察3组动物炎症介质、脏器功能及死亡率的变化.结果:3组动物均出现全身炎症反应综合征,M组动物血肿瘤坏死因子、内毒素含量以及肺和小肠髓过氧化物酶活性均显著高于I-R组和Z组.二次打击组72 h多器官功能障碍综合征(MODS)发病率和死亡率分别为48%和68%,显著高于两个单次打击组.结论:小剂量酵母多糖能诱发肠缺血-再灌注后全身炎症反应和MODS.
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