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Changes of I-κB kinase activation and its significance in traumatic lung injury

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
12
DOI:
10.3760/j.issn:1003-0603.2002.12.004
Key Word:
创伤;肺损伤,急性;I-κB激酶;核因子-κB;细胞因子

Abstract: 目的:探讨I-κB激酶(IKK)在创伤性急性肺损伤(ALI)病理变化中可能的作用机制.方法:复制创伤性ALI家兔模型,用原位杂交方法结合原位定量分析检测肺组织中IKKβ的mRNA表达,用凝胶电泳迁移率改变分析法(EMSA)和酶联免疫吸附(ELISA)法分别检测肺泡巨噬细胞(PAM)中核因子-κB(NF-κB)的活性和PAM培养上清液中TNF-a 、IL-6的含量.结果:创伤性ALI家兔组肺组织中IKK-β的mRNA表达(0.106 3±0.021 8)以及PAM中NF-κB活性(2 987.85±163.85)和上清液中 TNF-a、IL-6的含量[分别为(235.6±30.8) ng/L和(398.8±243.6) ng/L]均较正常对照组[分别为0.042 7±0.024 1、922.02±28.36、(36.4±8.0) ng/L和(78.6±39.4) ng/L]显著增高(P均<0.01).结论:蛋白激酶IKK的激活介导NF -κB活化和分泌高水平细胞因子在创伤性ALI的炎症反应中发挥重要作用.

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