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Effects of vasoactive agents on liver and renal functi on in septic patients
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1003-0603.2002.05.006
- Key Word:
- 脓毒症;去甲肾上腺素;多巴胺;多巴酚丁胺;肌酐;总胆红素
Abstract： 目的:探讨血管活性药物对脓毒症患者肝、肾功能的影响.方法:回顾性研究1997年1月-2001年6月外科ICU内使用血管活性药物超过 4日的脓毒症患者,记录用药前1日的急性生理学和慢性健康状况评分Ⅱ(APACHEⅡ) 、体循环平均动脉压等资料.患者分为大剂量多巴胺组、去甲肾上腺素加用小剂量多巴胺或多巴酚丁胺组及小剂量多巴胺或多巴酚丁胺组,比较用药前后血肌酐及总胆红素的变化.结果:大剂量多巴胺组用药后血肌酐及总胆红素均显著增高(P<0. 01和 P<0.05).去甲肾上腺素加用小剂量多巴胺或多巴酚丁胺对血肌酐及总胆红素均无显著影响.单用小剂量多巴胺或多巴酚丁胺可使血肌酐显著降低,但用药前后血总胆红素无显著差异.结论:使用小剂量多巴胺或多巴酚丁胺可能对脓毒症患者肝、肾等脏器的血液循环有利,可以逆转用去甲肾上腺素升压时对内脏灌流的不良影响.
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