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Effec ts of N-desulfated heparin on renal ischemia-reperfusion i njury in rats
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1003-0603.2002.04.003
- Key Word:
- 损伤,缺血-再灌注,肾;N-去硫酸肝素;P-选择素
Abstract： 目的:研究N-去硫酸肝素对大鼠肾缺血-再灌注损伤的防治作用.方法:建立肾缺血-再灌注损伤大鼠模型,实验动物随机分为正常对照组和N-去硫酸肝素治疗及非治疗组.观察大鼠治疗前后肾组织中P选择素表达、组织病理学与肾功能的改变,以及凝血指标[包括凝血酶原时间 (PT)和部分激活凝血时间(KPTT)]的变化.结果:缺血-再灌注后大鼠肾脏P-选择素表达增高 ,出现明显组织病理学改变,血清尿素氮(BUN)、肌酐(Cr)水平明显升高[分别为(14.54 ±0.67)mmol/L和(102.12±4.76)μmol/L];N-去硫酸肝素治疗组肾脏组织中P-选择素表达受抑(未出现棕黄色颗粒),病理学改变与肾功能损害减轻,且对PT和KPTT无明显影响.结论:N-去硫酸肝素对肾缺血-再灌注损伤具有防治作用,且对凝血指标PT和KPTT无明显影响.
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