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Polymorphism of tumor necrosis factor alpha and its relation with acute lung injury in people of Han nationality in Chongqing area
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1003-0603.2001.09.008
- Key Word:
- 肿瘤坏死因子-α;基因频率;肺损伤,急性;基因多态性
Abstract： 目的:探讨重庆地区汉族人肿瘤坏死因子-α(TNF-α)基因-308位点的多态性与急性肺损伤(ALI)的相关性.方法:对59例ALI患者用放射免疫分析法(RIA)测定TNF-α含量,用等位特异性聚合酶链反应(AS-PCR)方法分析血清TNF-α基因多态性变化,并与60名健康献血者对照.结果:①ALI组TNF-α含量[(1.883±0.106) μg/L]显著高于对照组[(1.129±0.077) μg/L],t=30.16,P<0.01;②ALI组TNF-α(-308A)等位基因频率(33.9%)显著高于对照组(6.7%),P<0.01;③TNF-α等位基因频率增高与ALI的易感性相关联,比值比(OR)为7.368,95%可信限(CI)为0.370～8.620.结论:重庆地区汉族人TNF-α基因-308位点的多态性与ALI相关联.
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