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Dynamic changes in vasoactive peptides in peripheral blood in acute myocardial infarction patients
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1008-6315.2000.11.067
- Key Word:
- 心肌梗死,急性;肿瘤坏死因子;一氧化氮;内皮素;神经肽Y;神经降压素;降钙素基因相关肽
Abstract： 目的:探讨血管活性肽在急性心肌梗死(AMI)病理生理中的作用.方法:采用化学比色法及放射免疫法测定44例AMI患者发病后即刻、第1日、第7日、第14日和第28日外周血肿瘤坏死因子α(TNFα)、一氧化氮(NO)、内皮素(ET)、神经肽Y(NPY)、神经降压素(NT)及降钙素基因相关肽(CGRP)水平.与另40例健康体检者的血管活性肽水平作对照研究.结果:在AMI患者发病后即刻和第1日的TNFα、ET、NPY、CGR P水平均明显高于对照组,P<0.01和P<0.001;而NO、NT水平则明显低于对照组( P均<0.01);TNFα与ET、NPY、CGRP呈显著正相关,而与NO、NT 呈显著负相关.在AMI发病后第7日,TNFα、ET、NPY、CGRP水平逐渐下降,N O、NT水平逐渐升高,到第28日上述变化仍未达到对照组水平.结论:血管活性肽对AMI的病理生理过程具有重要影响,并和AMI的严重程度相关.
- [1]M, Odeh.Tumor necrosis factor-alpha as a myocardial depressant substance.[J].1993,42.
- [2]J G, Clarke,G J, Davies,R, Kerwin,etc.Coronary artery infusion of neuropeptide Y in patients with angina pectoris.[J].1987,1.
- [3]H, Vierhapper,O, Wagner,P, Nowotny,etc.Effect of endothelin-1 in man.[J].1990,81.
- [4]F, Bussolino,G, Camussi,C, Baglioni.Synthesis and release of platelet-activating factor by human vascular endothelial cells treated with tumor necrosis factor or interleukin 1 alpha.[J].1988,263.
- [5]LARS EDVINSSON,PIERS EMSON,JAMES McCULLOCH,etc.Neuropeptide Y: Immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ[J].1984,122(2).
- [6]S, Moncada,R M, Palmer,E A, Higgs.Nitric oxide: physiology, pathophysiology, and pharmacology.[J].1991,43.
- [7]P, Ghezzi,C A, Dinarello,M, Bianchi,etc.Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells.[J].1991,3(3).