You Position: Home > Paper
Effects of high frequency oscillation combined with nitric oxide inhalation on pulmonary hypertension caused by acute hypoxia in rats
( views:96, downloads:4 )
- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2000.09.002
- Key Word:
- 肺动脉高压,急性;高频振荡通气;一氧化氮;急性缺氧
Abstract： 目的:观察高频振荡通气(HFO)联合低浓度一氧化氮(NO)吸入对急性缺氧大鼠肺动脉高压的治疗作用.方法:在HFO下,经气管插管给大鼠12%氧30分钟制成急性缺氧肺动脉高压模型,行肺泡再充气,吸入低浓度NO(10、5、2 mmol/L)对模型动物进行治疗,测定血流动力学参数和血气值.结果:2～10 mmol/L NO吸入均可逆转急性缺氧大鼠肺动脉压(PAP),收缩压(sPAP)从4.44～4.53 kPa(1 kPa=7.5 mmHg)降至3.38～3.48 kPa;平均压(mPAP)从2.58～2.87 kPa降至2.00～2.18 kPa;舒张压(dPAP)从2.20～2.70 kPa降至1.67～1.82 kPa.NO吸入前后体循环压和心率的变化无显著性差异(P均>0.05).PaO2、PaCO2、pH和肺内动静脉分流(s/t)均无显著性差异(P均>0.05).结论:HFO联合低浓度NO(2 mmol/L)吸入对大鼠急性缺氧性肺动脉高压有明显疗效;2～10 mmol/L NO吸入对急性缺氧大鼠肺动脉高压的降压效应与NO的浓度无明显剂量依赖性.
- [1]J D, Roberts,P, Lang,L M, Bigatello,etc.Inhaled nitric oxide in congenital heart disease.[J].1993,87.
- [2]O, Dyar,J D, Young,L, Xiong,etc.Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep.[J].1993,71.
- [3]陈贤楠,吴冀川,耿荣,等.一氧化氮吸入疗法的实验和临床研究[J].1996,(4).