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Clinical characteristics of severe traumatic patients with acute respiratory distress syndrome
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.1008-1372.2000.09.002
- Key Word:
- 创伤;呼吸窘迫综合征,急性;多脏器衰竭;临床特征
Abstract： 目的:探讨严重创伤并发急性呼吸窘迫综合征(ARDS)的临床特点.方法:对162例严重创伤、创伤严重度评分(ISS)≥16分者进行回顾性分析,46例并发ARDS,均发生了全身炎症反应综合征,其中31例发生多脏器衰竭(MOF).并对46例ARDS患者检测内皮素-1(ET-1)、肾上腺髓质素(ADM)和肿瘤坏死因子-α(TNF-α).结果:ISS≥25分者ARDS发生率为71.8%,显著高于ISS 16～25分者(28.2%).发生MOF患者血浆ET-1、ADM、TNF-α显著增高,且死亡组高于存活组.结论:创伤严重程度、感染、休克、原发性肺损伤和误吸是并发ARDS的主要危险因素.血浆ET-1、ADM、TNF-α水平提示SIRS在ADRS转归中有重要作用.
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