You Position: Home > Paper
Relation between vasoactive substances and cerebral vascular disease
( views:359, downloads:16 )
- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4904.2000.05.017
- Key Word:
- 脑血管病;肿瘤坏死因子;一氧化氮;内皮素;神经肽Y;神经降压素;降钙素基因 相关肽
Abstract： 目的: 探讨血管活性物质在脑血管病发病中的作用.方法: 采用化学比色法及放射免疫法检测114例急性脑血管病急性期、稳定期和恢复期患者及76例健康人外周血肿瘤坏死因子(TNF)、一氧化氮(NO)、内皮素(ET)、神经肽Y(NPY)、神经降压素(NT )及降钙素基因相关肽(CGRP)水平.结果: 急性期脑梗死和脑出血者血中TNF、NO、ET、NPY、CGRP水平较恢复期均明显升高(P<0 .05～P<0.001),ET与CGRP、ET与NO、NPY与NT的直线相关分析均具有显著的相关性(P均<0 .01);稳定期TNF、NO、ET、NPY水平仍高于对照组;恢复期上述指标接近正常水平.这种血管活性物质的变化在脑出血组尤为明显,且与脑梗死程度的轻重呈正相关.而NT水平在脑出血急性期明显下降(P<0.01),但在脑梗死各期均无明显变化(P均>0.05).结论: TNF、NO、ET等物质在急性脑血管的发病中可能起重要作用.
- [1]G K, Hansson.Immune and inflammatory mechanisms in the development of atherosclerosis.[J].1993,69(1 Suppl).
- [2].脑卒中患者临床神经功能缺损程度评分标准（1995）[J].1996,(6).
- [3]Davies Mark G.,Hagen Per-Otto.The Vascular Endothelium[J].1993.
- [4]A, Franco-Cereceda,A, Saria,J M, Lundberg.Differential release of calcitonin gene-related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain.[J].1989,135(2).
- [5]Klaus Fassbender,Siegbert Rossol,Thomas Kammer,etc.Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease[J].1994,122(2).
- [6].各类脑血管疾病诊断要点[J].1996,(6).
- [7].Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing[J].1983,304(5922).
- [8]H, Vierhapper,O, Wagner,P, Nowotny,etc.Effect of endothelin-1 in man.[J].1990,81.
- [9]LARS EDVINSSON,PIERS EMSON,JAMES McCULLOCH,etc.Neuropeptide Y: Immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ[J].1984,122(2).