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The effect and mechanism of ginkgo biloba extract on stressinduced gastric ulceration in rats
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.2095-1477.2000.02.042
- Key Word:
- 银杏叶提取物;应激;自由基;肌电活动;溃疡
Abstract： 目的:探讨银杏叶提取物(EGb)对大鼠应激性胃溃疡发生的保护作用及其机制.方法:雄性Wistar大鼠,随机分成对照组和EGb处理组;以冷拘束法建立应激性溃疡模型,通过胃窦部埋置电极记录应激状态胃平滑肌自发电活动的变化,并测定血浆和胃粘膜组织丙二醛(MDA)含量和胃粘膜的病理改变.结果:EGb10～40 mg/kg预处理可显著压抑应激所致的胃肌电活动紊乱及血浆和胃粘膜组织MDA水平的异常升高(P<0.05或P<0.01),使胃粘膜溃疡指数明显降低(P均<0.05),并具有剂量依从性.结论:EGb对冷束缚应激引起的大鼠胃粘膜损伤有明显的保护作用,其机制可能是通过改善胃平滑肌动力障碍和清除自由基来实现的.
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