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Effect of thymosin on the expression of G-proteins in asthmatic guinea pigs

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Author:
No author available
Journal Title:
CHINESE CRITICAL CARE MEDICINE
Issue:
1
DOI:
10.3760/j.issn:1003-0603.2000.01.005
Key Word:
G蛋白,肺组织;哮喘,豚鼠;胸腺素

Abstract: 目的:研究哮喘豚鼠肺组织G蛋白α亚基含量的表达变化及胸腺素对其的影响.方法:用卵蛋白雾化吸入致敏的方法复制豚鼠哮喘模型,并用胸腺素治疗,Western blot杂交分析法测定Gα含量.结果:哮喘组豚鼠肺组织Giα(126%±11%)、Gqα(122%±12%)较正常对照组显著升高(P均<0.05);而胸腺素组Giα、Gqα(分别为97%±9%和98%±11%)较哮喘组显著降低(P均<0.05);胸腺素组Gsα(107%±6%和104%±5%)无显著变化(P均>0.05).结论:哮喘肺组织Giα、Gqα表达增加在哮喘发病中可能占有一定地位,而胸腺素通过降低Giα、Gqα在哮喘豚鼠肺组织的表达变化达到了治疗或缓解哮喘的目的.

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