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Effect of hypothermia on the plasma levels of adrenomedullin,endothelin1 and hemodynamics in dogs
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1003-0603.1999.11.005
- Key Word:
- 低温;肾上腺髓质素;内皮素;血流动力学
Abstract： 目的:通过低温犬模型,探讨低温对机体血浆肾上腺髓质素(ADM)和内皮素(ET)含量及血流动力学的影响.方法:12条犬随机分为常温[中心温度控制在(38.5±0.5)℃]及低温[中心温度控制在(32.0±0.5)℃]2组,在血流动力学监测下测定动物静脉血ADM和ET.结果:实验犬血浆ADM、ET水平常温组为(22.30±1.80)ng/L和(82.76±14.42)ng/L;低温组降温1小时其值分别为(34.70±2.10)ng/L和(165.24±12.56)ng/L,低温犬血浆ADM、ET水平均非常明显增高(P均<0.01),血流动力学指标MAP、PAP、PCWP和CO均发生明显变化(P均<0.05).结论:低温状态下犬血浆ADM及ET均明显增高,可能在机体血流动力学的调节过程中起重要作用.
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