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Comparative effects of fluvastatin and L-arginine on vasorelaxation and atherosclerosis in hyperlipidic rabbits
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1003-0603.1999.09.004
- Key Word:
- 氟伐他汀;L-精氨酸;血管舒张功能;动脉粥样硬化
Abstract： 目的:探讨氟伐他汀是否能改善高血脂兔内皮依赖性血管舒张功能及减轻其动脉粥样硬化形成,并与L精氨酸进行比较.方法:日本大耳白雄兔60只等分为4组:①正常饲料组(NC组);②1%胆固醇饲料组(CC组);③1%胆固醇饲料并用2.25 g/kg L-精氨酸溶液灌胃组(L-arg组);④1%胆固醇饲料并用20 mg/kg氟伐他汀溶液灌胃组(FT组).实验共16周.动物喂养10周后先用3 mg戊巴比妥皮下注射麻醉抽取耳中央动脉血,作生化分析,剥离主动脉(自起始部到髂动脉分叉处)起始段4 mm制成动脉环用于主动脉反应性研究,其余部分作斑块面积测定.结果:同CC组和L-arg组相比,FT组的血清总胆固醇(TC)和低密度脂蛋白-胆固醇(LDL-C)分别降低28%±5%和37%±7%,而高密度脂蛋白-胆固醇(HDL-C)升高10%±4%;CC组和L-arg组上述指标相比无差异,但均明显高于NC组(P均<0.001);CC组动物主动脉对乙酰胆碱的内皮依赖的血管舒张功能明显损害,相比之下,L-arg组和FT组动物主动脉对乙酰胆碱的内皮依赖舒张功能损害较轻,L-arg组比FT组损害更轻;L-arg组和FT组的动脉粥样斑块面积显著少于CC组,但是L-arg组和FT组斑块面积的形成量相比无显著差异(P>0.05).结论:氟伐他汀能够改善高血脂兔的内皮依赖性血管舒张功能,但L精氨酸优于氟伐他汀;对动脉粥样斑块面积形成的影响氟伐他汀和L精氨酸功能近似.
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