You Position: Home > Paper
Effect of lactic acidosis on ventricular systolic function in dogs
( views:196, downloads:12 )
- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1003-0603.1999.07.004
- Key Word:
- 酸中毒,乳酸;收缩功能,心室;超声心动图;血流动力学
Abstract： 目的:观察实验性乳酸酸中毒对犬心室收缩功能的影响.方法:应用超声心动图和血流动力学监测技术,观察9只经静脉麻醉、气管插管、连续静脉滴注0.5mol/L的DL乳酸液后,健康杂种犬心室收缩功能变化;每30分钟采血液、心室、主动脉压力及超声心动图数据1次.结果:主动脉瓣血流平均加速度、左室射血分数、左室周边缩短速率、肺动脉瓣血流平均加速度、右室面积变化率和右室射血分数均降低(P均<0.05),心室收缩末径较舒张末径增大更明显(P均<0.05).结论:乳酸酸中毒降低心室收缩功能,尤其降低心肌收缩力.
- [1]D.A.Eisner,G.L.Smith,S.C.O'Neill.The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle[J].1993,88(5).
- [2]K, Kiuchi,D E, Vatner,N, Uemura,etc.Mechanisms of alpha 1-adrenergic vascular desensitization in conscious dogs.[J].1992,71.
- [3]A I, Arieff.Indications for use of bicarbonate in patients with metabolic acidosis.[J].1991,67(2).