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The potential role of prostaglandins and thromboxane A2 in the development of renal injury associated with acute necrotizing pancreatitis in rats
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1003-0603.1999.05.004
- Key Word:
- 胰腺炎;急性;肾脏损害;前列环素;血栓素A2
Abstract： 目的:探讨前列环素(PGI2)、血栓素A2(TXA2)在急性坏死性胰腺炎并发肾损害发病机制中的作用.方法:采用胰胆管结扎、胰腺被膜下注射5%牛磺胆酸钠复制急性坏死性胰腺炎肾损害大鼠模型,以放射免疫方法动态测定术后24、48小时肾静脉血浆和肾组织中血栓素B2(TXB2)、PGI2水平,并观察尿素氮(BUN)、血肌酐(SCr)的改变.结果:随着急性坏死性胰腺炎病程进展,肾静脉血浆和肾组织中TXB2、6-酮-前列腺素1α(6-keto-PGF1α)水平逐渐升高,TXB2水平升高较6-keto-PGF1α为甚,TXB2/6-keto-PGF1α比值增大,BUN、Cr亦显著提高.结论:TXA2和PGI2平衡紊乱是急性坏死性胰腺炎并发肾损害的主要因素之一.
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