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Influences of cell adhesion molecules expression on pulmonary neutrophil aggregation in hemorrhagic necrotic pancreatitis
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1003-0603.1999.05.003
- Key Word:
- 胰腺炎;出血性;坏死性;急性;肺损伤;急性;中性粒细胞;细胞间粘附分子
Abstract： 目的:探讨急性出血坏死性胰腺炎(AHNP)时中性粒细胞(PMN)聚集于肺脏的机制.方法:利用AHNP并发急性肺损伤(ALI)大鼠模型,采用免疫组化技术等方法,动态观察AHNP后大鼠肺脏实质细胞间粘附分子1(ICAM1)、PMN表面巨噬细胞分化抗原1(CD11b/CD18)的表达改变和PMN肺脏聚集的变化.结果:AHNP后,肺脏ICAM1表达逐渐增加,与PMN肺脏聚集程度呈显著正相关,而PMN表面CD11b/CD18在AHNP后1小时即迅速表达至高峰,并持续24小时保持此高表达状态.结论:AHNP后,PMN在肺脏的大量聚集是建立在PMN表面CD11b/CD18与肺实质细胞ICAM1高表达的基础之上,而ICAM1为这一粘附过程中的可变因素,是影响PMN粘附并聚集于肺脏的主要因素.
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