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The relationship between the progression of diabetic nephropathy and angiotensin I converting enzyme gene insertiondeletion polymorphism in noninsulindependent diabetes mellitus
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- Author:
- No author available
- Journal Title:
- CHINESE CRITICAL CARE MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1003-0603.1999.04.006
- Key Word:
- 糖尿病,非胰岛素依赖型;糖尿病肾病;血管紧张素转换酶基因;多态性
Abstract： 目的:探讨非胰岛素依赖型糖尿病(NIDDM)肾病(DN)病情进展与血管紧张素转换酶(ACE)基因插入缺失(ID)多态性的关系.方法:用PCR方法分别检测了92例不同程度蛋白尿的NIDDM患者的ACE基因型.结果:随着DN蛋白尿程度加重,DD型频率逐渐增高(微白蛋白尿期17%,显性蛋白尿期25%,肾功能不全期46%),而II型频率逐渐下降(在3组分别为33%、29%和8%),DI型在3组分布无显著性差异;在肾功能不全期组,DD型频率(46%)显著高于肾功能正常期组(20%),II型频率(8%)显著低于肾功能正常期组(32%),DI型频率在2组无显著性差异.结论:DD型NIDDM患者发生DN后,病情进展较快,DD型是DN恶化的促进因素;II型为保护性因素.
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