Research progress of prognostic protein biomarkers associated with esophagus squamous cell carcinoma

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Author:
LI Hui(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Thoracic Surgery Ⅰ, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China)
SHEN Lu-yan(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Thoracic Surgery Ⅰ, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China)
CHEN Ke-neng(Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Department of Thoracic Surgery Ⅰ, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China)
Journal Title:
Chinese Journal of Gastrointestinal Surgery
Issue:
Volume 15, Issue 09, 2012
DOI:
10.3760/cma.j.issn.1671-0274.2012.09.034
Key Word:
Esophageal squamous cell carcinoma;Prognosis ; Molecular markers

Abstract: Esophageal cancer (EC) is one of the common malignant tumors in China.Esophagectomy based on multi-disciplinary principle improves the quality of life and survival of esophageal cancer patients,but a lot of patients will suffer recurrence or metastasis after surgery.TNM stage is the most important factor which affects the prognosis of patients with esophageal cancer.Besides,there are other prognostic factors,such as abnormal expression of the proteins.Exploration of these proteins may provide new clues to improve prognosis in esophageal squamous cell cancer (ESCC).We reviewed the literatures related to abnormal protein expression in ESCC,and tried to elucidate the prognostic value and potential clinical application of these proteins in ESCC.

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