Abstract： Objective To explore the safety and short-term efficacy of laparoscopic transhiatal proximal gastrectomy in patients with adenocarcinoma of the esophagogastric junction.Methods From Aug 2008 to May 2011,98 patients with adenocarcinoma of the esophagogastric junction underwent laparoscopic transhiatal proximal gastrectomy.Clinical data were analyzed retrospectively including operative time,estimated bleeding,length of resection,lymph node dissection,and short-term postoperative complications.Results Ninety-six patients underwent laparoscopic transhiatal proximal gastrectomy successfully and 2 were converted to open operation (one for combined splenectomy and the other combined splenectomy and resection of the tail of the pancreas).The mean operative time was (224.1±33.7) min and the mean blood loss was (69.4±26.1) ml.The mean length of esophageal resection was (4.0±0.6) cm and the resection margin was negative.The number of lymph node removed was 16.4± 5.7.Pleural laceration occurred in 14 cases and spleen injury occurred in 3 case during operation.There was one anastomotic leakage.There were no postoperative mortalities,bleeding,anastomotic stenosis and wound infection.After follow-up ranging from 3 to 30 months,the value of reflux diagnostic questionnaire (RDQ) was 9.9±4.4 at 1 month and 9.3±4.3 at 3 months postoperatively.No incision metastasis was found and 5 patients died.Conclusion Laparoscopic transhiatal proximal gastrectomy is safe for patients with adenocarcinoma of the esophagogastric junction and the short-term clinical outcomes are favorable.