Abstract： Objective To compare laparoscopic Nissen fundoplication (LNF)and Toupet laparoscopic fundoplication (LTF)with respect to treatment outcomes and postoperative complications.Methods PubMed,Medline,Embase and the Cochrane Library were searched.Only randomized controlled trials (RCTs) comparing laparoscopic Nissen and Toupet fundoplication were included.Outcomes evaluation included occurrences of heartburn,reflux,difficulty swallowing,chest pain,abdominal distention,failure to hiccup,diarrhea,and early complications and degree of patient satisfaction at early (three to six months) and later (one to three years) post-operative periods.Results Of 939 patients in seven RCTs,478 received LNF and 461 received LTF.For both groups,control of reflux was good and occurrence of heartburn was similar (P＞0.05).A lower incidence of postoperative dysphagia for both early and later post-operative periods,but a higher overall complication rate in early post-operative period were observed in the LTF group (P＜0.05).Patient satisfaction was similar (P＞0.05).Conclusions LNF and LTF are both safe and effective.The adoption of procedure should be based on the patient status and surgeon experience.