Abstract： Objective To prospectively evaluate the safety and efficacy of nickel-titanium temperature-dependent memory-shape device (CAR27) for colorectal anastomosis. Methods Sixty colorectal cancer patients were randomly divided into two groups and received colorectal anastomosis with CAR27 or traditional stapling device. Complications, bowel function return, and the extrusion of anastomosis ring were prospectively monitored. Results Both CAR27 and stapler group had one case of anastomotic leakage. Other complications such as stricture or obstruction were not found. Time for anastomosis of the two groups were (10.1±1.2) minutes and (11.2±2.1) minutes respectively. Time to first flatus was (3.2±1.2) days and (3.5±1.4) days respectively. Time to food intake resumption was (4.0±1.4) days and (4.3±1.3) days respectively. The differences above between the two groups were not statistically significant (P>0.05). The ring was expelled with stool within 7-16 days. The two groups were similar in operative time and the return of bowel function. Conclusion CAR27 is safe and simple for colorectal anastomosis.