Abstract： Objective To evaluate laparoscopic radical gastrectomy for early gastric cancer.Methods A total of 204 patients with early gastric cancer undergoing laparoscopic-assisted radical gastrectomy or open radical gastrectomy between October 2004 and December 2009 were retrospectively reviewed and analyzed. Patients were divided into laparoscopic group (LAP, n=78) and open group (OPEN, n=126). Operative time, blood loss, time to passage of flatus, postoperative hospital stay,complications and pathologic findings were compared between the two groups. Results Compared to the OPEN group, operative time in the LAP group was significantly shorter[(202.9±45.6) min vs. (219.8±45.2) min, P＜0.05], blood loss was less[(144.5±146.5) ml vs. (245.0±146.4) ml, P＜0.05], time to passage of flatus was shorter[(3.1±1.1) d vs.(4.5±1.6) d, P＜0.05], postoperative hospital stay was shorter[(10.8±1.2) d vs. (12.4±3.8) d, P＜0.05]. However, the two groups were comparable with regard to postoperative complication rate ( 10.3% vs. 12.7%, P＞0.05), proximal resection margin [(4.0±1.9) cm vs. (4.2±1.7) cm, P＞0.05], distal resection margin [(3.6±1.7) cm vs. (3.5±1.8) cm, P＞0.05],number of harvested lymph node(13.1±6.5 vs. 14.5±8.2, P＞0.05). The median follow up was 22(2-64) months. There were no tumor recurrences or metastases in the LAP group. In the OPEN group, only 1 patient died from peritoneal metastasis. Total hospital costs between the two groups were similar (P＞0.05). Conclusion Laparoscopic radical gastrectomy is a safe, feasible, effective,and less invasive surgery for early gastric cancer.